Pre-Meeting Scientific Activities

Wednesday, June 5, 2019

Scientific Workshops

Researchers working in Spanish labs invite young investigators to a hands-on visit on 5th of June. This will allow young researchers to get familiar with the laboratory’s research and techniques. Interested researchers should have submitted an abstract as first author to the T21RS International Conference 2019.

Alzheimer Down Unit, Hospital de la Santa Creu i Sant Pau
Tissue Engineering Unit, Center for Genomic Regulation
Cellular and Systems Neurobiology, Center for Genomic Regulation
Starlab Barcelona

Industry Session

16:00-18:00 Top Challenges Facing the Pharmaceutical Industry in Down syndrome Drug Development

The Market: Is it large enough to justify drug development? (Pier-Vincenzo Piazza, AELIS Pharma)

Translationality: Are we using the most adequate tools in the evaluation of drug effects in the transfer from preclinical studies to clinical trials

Mouse-based genetic modeling of Down syndrome. (William C Mobley, USC San Diego)

Bordeaux Maze Test  (Rafael de la Torre, IMIM)

Clinical Trials Outcomes: Difficulties in finding primary outcomes acceptable for regulatory authorities (FDA, EMA)

The NIH Toolbox Cognitive Battery for intellectual disabilities (Len Abbeduto, MIND Institute)

Regulatory Aspects: The EMA perspective in drug development of orphan drugs targeting neurodevelopmental disorders (Fernando Mendez, EMA Committee for Orphan Medicinal Products)

Registration cost: 25 €       Industry session

Pre-Meeting Scientific Tours

09.00 – 12:00  Visit to three research centres located around the Barcelona Biomedical Research Park (PRBB, www.prbb.org), which perform cutting-edge scientific research that can be relevant for further understanding the aetiology of Down syndrome.  FULLY BOOKED

  • Mesoscopic Imaging Facility at the European Molecular Biology Laboratory (EMBL). The facility houses state-of-the-art imaging services enabling scientists worldwide to access mesoscopic imaging technologies. These include Optical Projection Tomography (OPT) and Light Sheet Microscopy (SPIM), which are specifically designed for 3- and higher-dimensional studies of multi-cellular systems ranging in size up to adult rodent organs. https://www.embl.es/research/unit/index.html
  • Center for Genomic Regulation (CRG). This CRG is an international biomedical research institute of excellence that has developed the ‘Stick Out Your Tongue’ (‘Saca la Lengua’) project. This is a citizen’s science project that aims to study the mouth’s microbiome and its possible relationship with our environmental characteristics and lifestyle, with specific data on Down syndrome population. sacalalengua.org/stick-out-your-tongue
  • Barcelonaβeta Brain Research Center (BBRC)- Pasqual Maragall Foundation (FPM). The BBRC is a research center dedicated to the prevention of Alzheimer’s disease and the study of cognitive functions affected in healthy and pathological aging. It was created in 2012 by the Pasqual Maragall Foundation, and it offers researchers and collaborators three specialised facilities at the service of brain research, including neuroimaging acquisition services, a clinical trial unit, and a cognition laboratory. https://fpmaragall.org/en/